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Research Papers

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· Mitochondrial DNA deletions induce the AMPK energy stress pathway and result in decreased secretion of some proteins., May 2007

· Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells., April 2007

· Mitochondrial DNA Deletions and Chloramphenicol Treatment Stimulate the Autophagic Transcript ATG12., April 2007

· Mitochondrial frataxin interacts with ISD11 of the Nfs1/ISCU complex and multiple mitochondrial chaperones, March 2007

· Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts, January 2007

· Knockdown of frataxin causes loss of aconitase activity, induction of oxidative stress and induction of heme transcripts, October 2006

· Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts, May 2006

· Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript, May 2006

· Frataxin, Iron–Sulfur Clusters, Heme, ROS, and Aging, April 2006

· A low dose of ethidium bromide leads to an increase of total mitochondrial DNA while higher concentrations induce the mtDNA deletion in a human neuronal cell line, December 2005

· Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells, October 2005

· Frataxin, iron-sulfur clusters, heme, ROS and aging, September 2005

· Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process, February 2005

· Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells, May 2003

· High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader, October 2002

· A neutral theory predicts multigenic aging and increased concentrations of deleterious mutations on the mitochondrial and Y chromosomes, September 2002

· Fixation of deleterious alleles, evolution and human aging, May 2002

· Reproducible quantitative PCR of mitochondrial and nuclear DNA copy number using the LightCycler, 2002

· Quantification of human mitochondrial DNA in a real time PCR, March 2002

· Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells, February 2002

· Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis, February 2002

· Frataxin Expression Rescues Mitochondrial dysfunctions in FRDA cells, July 2001

· Bcl-2 Does Not Inhibit the Permeability Transition Pore in Mouse Liver Mitochondria, July 2000

· Derivation of a Simple Formula that relates mtDNA mutation frequency to age, September 2000

· The Fridreich's Ataxia Mutation Confers Cellular Sensitivity to Oxidant Stress Which is Rescued by Chelators of Iron and Calcium and Inhabitors of Apoptosis, March 1999

· Mitochondria in Organismal Aging and Degeneration, February 1999

· dATP Causes Specific Release of Cytochrome C From Mitochondria, September 1998

· Analysis of Oxygen Consumption and Mitochondrial Permeability With Age in Mice, April 1998

· Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor CytohromeC, March 1998

· mtDNA Mutations Confer Cellular Sensitivity to Oxidant Stress That is Partially Rescued by Calcium Depletion and Cyclosporin A, October 1997

· The Rate of Mitochondrial Mutagenesis is Faster in Mice Than Humans, July 1997

· Mutiple Orgins of a Mitochondrial Mutation Conferring Deafness, March 1997

· BCL-2 Potentiates the Maximal Calcium Uptake Capacity of Neural Cell Mitochondria, September 1996

· Mitochondria and Risk for Deafness, March 1995

· BCL2 Translocation Frequency Rises With Age in Human, September 1994

· Mice With Duplications and Deletions at the Tme Locus Have Altered MnSOD Activity, September 1994

· A Molecular Basis for Human Hypersensitivity to Aminoglycoside Antibiotics, September 1993

· Mitochondrial Ribosomal RNA Mutation Associated With Both Antibiotic-Induced and Non-Syndromic Deafness, July 1993

· Mosaicism for a Specific Somatic Mitochondrial DNA Mutation in Adult Human Brain, December 1992

· A Pattern of Accumulation of a Somatic Deletion of Mitochondrial DNA in Aging Human Tissues, August 1992

· Detection of a Specific Mitochondrial DNA Deletion in Tissues of Older Humans, December 1990

Last Updated: January 22, 2008